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Enzyme Replacement Therapy Market Size, Share & Growth | 2030

Global Enzyme Replacement Therapy Market

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Segments - by Route of Administration (Oral, Parenteral), Therapeutic Conditions (Gaucher Disease, Fabry Disease, Pompe Disease, SCID, MPS, Other Disease), and Regions (North America, Latin America, Europe, Asia Pacific and Middle East & Africa) - Global Industry Analysis, Growth, Share, Size, Trends, and Forecast 2020 – 2027

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140 Pages

2020-01-14
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Author :

Raksha Sharma

Fact-checked by :

Vineet Pandey

Editor :

Vishal Golekar

Report Description

Enzyme Replacement Therapy Market Outlook

The global enzyme replacement therapy market was valued at USD 9,955.4 Million in 2019 and is projected to reach USD 16,362.2 Million by 2027, expanding at a CAGR of 6.8% during the forecast period. Enzyme replacement therapy (ERT) is one of the important medical treatments prescribed to provide the enzymes that are deficient in the body. It replenishes the deficient enzymes in the patient’s body either through the intravenous (IV) or oral routes of administration. The IV route is widely accepted by people, these drugs are easily and rapidly absorbed in the body.

Enzyme deficiencies in body can hamper the metabolism of glycogen, which results in the accumulation of glycogen in tissue, bones, and cardiac muscle. Deficiency of enzyme can result in a life-changing or life-threatening conditions. Enzyme replacement therapy is used for the treatment of ailments such as Gaucher Disease, Fabry Disease, Pompe Disease, SCID, and MPS Disease. These diseases are genetic disorders and can be transferred from parents to their children, if both the parents suffer from the ailment. These diseases cannot be cured completely; however, they can be controlled by replacing the enzymes that are lacking in the human body.

In terms of route of administration, the enzyme replacement therapy market has been bifurcated into injectable agents and oral agents. Solid dosage form in enzyme replacement therapy are given through the oral route of administration to fulfil the enzyme deficiency in the body. Enzyme replacement therapy through oral route include the tablets dosage form containing the enzyme.

These enzymes are administered to fulfil the enzyme deficiency in the patient’s body. Zavesca is the oral drug developed by Actelion Pharmaceuticals Ltd indicated for the treatment of Gaucher’s disease. The oral route is more convenient than the parenteral route, as these drugs are easy to store and transport. Moreover, tablets are premeasured doses, which eliminates the need for measuring the medicine.

These factors are fuelling the growth of oral route of administration segment. Parenteral and oral medicines are available in market and are used for the treatment of ERT to treat diseases such as Gaucher’s diseases and Fabry diseases. Key players in the market are focused on developing drugs for both these routes of administration.

Enzyme Replacement Therapy Market Dynamics

Increased Prevalence of Chronic Diseases

Increasing prevalence of chronic diseases and life-threatening lysosomal storage diseases such as Gaucher, Pompe, Fabry, and SCID is expected to boost the global enzyme replacement therapy market. Rising awareness among people about the availability of ERT is encouraging and driving the market growth.

Technological Advancement Leading to Adoption of Technologies

Growing technological advancements have led to the adoption of technologies, which has increased the focus of manufacturers on drug development processes and the development of innovative therapies. This, in turn, is expected to propel the market growth during the forecast period. High absorption rate and rapid drug delivery through parenteral route of administration is driving the demand for parenteral dosage. Increasing financial support for rare diseases (including lysosomal storage diseases) by government and non-governmental organizations (NGOs) is projected to boost the market.

Segmental Outlook

On the basis of route of administration, the enzyme replacement therapy market has been divided into oral and parenteral. Parenteral and oral medicines are available in the market and are used for the treatment of ERT to treat diseases such as Gaucher’s diseases and Fabry diseases. Key players in the market are focused on developing drugs for these routes of administration.

Solid dosage form in enzyme replacement therapy are given through the oral route of administration to fulfil the enzyme deficiency in the body. Enzyme replacement therapy through oral route which includes the tablets dosage form containing the enzyme. These enzymes are administered to fulfil the enzyme deficiency in the patient’s body.

Zavesca is the oral drug developed by Actelion Pharmaceuticals Ltd indicated for the treatment of Gaucher’s disease. The oral route is more convenient than the parenteral route, as these drugs are easy to store and transport. Moreover, tablets are premeasured doses, which eliminates the need for measuring the medicine. These factors are fuelling the growth of oral route of administration segment.

Parenteral route of administration in enzyme replacement therapy are given through the intravenous (IV) route, which is a fast route of delivery and shows rapid absorption as compared to oral route of administration. High availability of a large variety of parenteral enzyme replacement therapy is driving the demand of parenteral ERT, thus making it highly preferred treatment type for EMT. Cerezyme (imiglucerase), VPRIV (velaglucerase alfa), and ELELYSO (taliglucerase alfa) are major drugs used for injections and providing treatment for Gaucher’s disease as injectable agents.

Based on therapeutic conditions, the enzyme replacement therapy market has been segmented into Gaucher’s diseases, Fabry disease, Pompe diseases, Severe Combined Immunodeficiency (SCID), Mucopolysaccharidosis (MPS) disease, and others. ERT is prescribed to treat several diseases, especially to people who have a particular enzyme deficiency. Increasing prevalence of such diseases is expected to drive the enzyme replacement therapy market.

Regional Outlook

In terms of regions, the market has been fragmented into North America, Europe, Asia Pacific, Latin America, and Middle East & Africa. North America is a promising region for the market. It constituted a 31.1% share of the market in 2019. Asia Pacific held significant market share of 25.7% in 2019. Availability of technological advancements and awareness among people drive the market in North America, followed by Europe. A majority of manufacturers are focused on developing the enzyme replacement therapy for treating a number of diseases.

This is expected to boost the market during the forecast period. The market in Asia Pacific is expected to grow at a significant pace due to increasing population and growing prevalence of chronic and rare diseases.

Segments

Types

Oral
Parenteral

Therapeutic Condition

Gaucher Disease
Fabry Disease
Pompe Disease
MPS Disease
Other Diseases

Regions

North America
- U.S.
- Canada
Latin America
- Brazil
- Mexico
- Rest of Latin America
Europe
- Germany
- France
- Italy
- U.K.
- Spain
- Russia
- Rest of the Europe
Asia Pacific
- China
- Japan
- South Korea
- India
- Australia
- South East Asia (SEA)
- Rest of Asia Pacific
Middle East & Africa (MEA)
- Saudi Arabia
- South Africa
- UAE
- Rest of MEA

Key Players

Sanofi
Takeda Pharmaceutical Company Limited
BioMarin
AbbVie Inc.
Alexion Pharmaceuticals, Inc
Horizon Therapeutics plc
RECORDATI S.p.A.
PROTALIX BIOTHERAPEUTICS, INC.
Allergan
Pfizer Inc.
Leadiant Biosciences, Ltd.

Competitive Landscape

Key players in the market include Sanofi, Takeda Pharmaceutical Company Limited, BioMarin, AbbVie Inc, Alexion Pharmaceuticals, Inc., Horizon Therapeutics plc, RECORDATI S.p.A., PROTALIX BIOTHERAPEUTICS, INC., Allergan, Pfizer Inc., and Leadiant Biosciences, Ltd. These companies are considered as key manufacturers of enzyme replacement based on their revenue, research & development (R&D) activities, regional presence, and supply chain management system.
The players are adopting key strategies such as acquisition, product launch, and geographical expansion where potential opportunity for the enzyme replacement is added in the company’s capacity.
In March 8, 2018, Sanofi acquired Bioverativ Inc. The acquisition has helped the company strengthen its pharmaceutical segments. The company’s net sales at a constant exchange rate rose by 2.5%, reflecting the acquisition of Bioverativ Inc.’s rare blood disorder products.
In 2018, January 8, 2019, Takeda Pharmaceutical Company Limited acquired SHIRE PLC. The acquisition helped the company with a substantial rise in their product offerings and their geographical presence.

Key Benefits for Industry Participants & Stakeholders

In-depth Analysis of the Global Enzyme Replacement Market
Historical, Current and Projected Market Size in terms of Value
Potential & Niche Segments and Regions Exhibiting Promising Growth Covered
Industry Drivers, Restraints and Opportunities Covered in the Study
Recent Industry Trends and Developments
Competitive Landscape & Strategies of Key Players
Neutral Perspective on Global Enzyme Replacement Market Performance

Table Of Content

Chapter 1 Executive Summary
Chapter 2 Assumptions and Acronyms Used
Chapter 3 Research Methodology
Chapter 4 Enzyme Replacement Therapy Market Overview
   4.1 Introduction
      4.1.1 Market Taxonomy
      4.1.2 Market Definition
      4.1.3 Macro-Economic Factors Impacting the Market Growth
   4.2 Enzyme Replacement Therapy Market Dynamics
      4.2.1 Market Drivers
      4.2.2 Market Restraints
      4.2.3 Market Opportunity
   4.3 Enzyme Replacement Therapy Market - Supply Chain Analysis
      4.3.1 List of Key Suppliers
      4.3.2 List of Key Distributors
      4.3.3 List of Key Consumers
   4.4 Key Forces Shaping the Enzyme Replacement Therapy Market
      4.4.1 Bargaining Power of Suppliers
      4.4.2 Bargaining Power of Buyers
      4.4.3 Threat of Substitution
      4.4.4 Threat of New Entrants
      4.4.5 Competitive Rivalry
   4.5 Global Enzyme Replacement Therapy Market Size & Forecast, 2017-2027
      4.5.1 Enzyme Replacement Therapy Market Size and Y-o-Y Growth
      4.5.2 Enzyme Replacement Therapy Market Absolute $ Opportunity
Chapter 5 Global Enzyme Replacement Therapy Market Analysis and Forecast By Route of Administration
   5.1 Introduction
      5.1.1 Key Market Trends & Growth Opportunities By Route of Administration
      5.1.2 Basis Point Share (BPS) Analysis By Route of Administration
      5.1.3 Absolute $ Opportunity Assessment By Route of Administration
   5.2 Enzyme Replacement Therapy Market Size Forecast By Route of Administration
      5.2.1 Oral
      5.2.2 Parenteral
   5.3 Market Attractiveness Analysis By Route of Administration
Chapter 6 Global Enzyme Replacement Therapy Market Analysis and Forecast By Therapeutic Condition
   6.1 Introduction
      6.1.1 Key Market Trends & Growth Opportunities By Therapeutic Condition
      6.1.2 Basis Point Share (BPS) Analysis By Therapeutic Condition
      6.1.3 Absolute $ Opportunity Assessment By Therapeutic Condition
   6.2 Enzyme Replacement Therapy Market Size Forecast By Therapeutic Condition
      6.2.1 Gaucher Disease
      6.2.2 Fabry Disease
      6.2.3 Pompe Disease
      6.2.4 SCID
      6.2.5 MPS Disease
      6.2.6 Other Diseases
   6.3 Market Attractiveness Analysis By Therapeutic Condition
Chapter 7 Global Enzyme Replacement Therapy Market Analysis and Forecast by Region
   7.1 Introduction
      7.1.1 Key Market Trends & Growth Opportunities by Region
      7.1.2 Basis Point Share (BPS) Analysis by Region
      7.1.3 Absolute $ Opportunity Assessment by Region
   7.2 Enzyme Replacement Therapy Market Size Forecast by Region
      7.2.1 North America
      7.2.2 Europe
      7.2.3 Asia Pacific
      7.2.4 Latin America
      7.2.5 Middle East & Africa (MEA)
   7.3 Market Attractiveness Analysis by Region
Chapter 8 Coronavirus Disease (COVID-19) Impact
   8.1 Introduction
   8.2 Current & Future Impact Analysis
   8.3 Economic Impact Analysis
   8.4 Government Policies
   8.5 Investment Scenario
Chapter 9 North America Enzyme Replacement Therapy Analysis and Forecast
   9.1 Introduction
   9.2 North America Enzyme Replacement Therapy Market Size Forecast by Country
      9.2.1 U.S.
      9.2.2 Canada
   9.3 Basis Point Share (BPS) Analysis by Country
   9.4 Absolute $ Opportunity Assessment by Country
   9.5 Market Attractiveness Analysis by Country
   9.6 North America Enzyme Replacement Therapy Market Size Forecast By Route of Administration
      9.6.1 Oral
      9.6.2 Parenteral
   9.7 Basis Point Share (BPS) Analysis By Route of Administration
   9.8 Absolute $ Opportunity Assessment By Route of Administration
   9.9 Market Attractiveness Analysis By Route of Administration
   9.10 North America Enzyme Replacement Therapy Market Size Forecast By Therapeutic Condition
      9.10.1 Gaucher Disease
      9.10.2 Fabry Disease
      9.10.3 Pompe Disease
      9.10.4 SCID
      9.10.5 MPS Disease
      9.10.6 Other Diseases
   9.11 Basis Point Share (BPS) Analysis By Therapeutic Condition
   9.12 Absolute $ Opportunity Assessment By Therapeutic Condition
   9.13 Market Attractiveness Analysis By Therapeutic Condition
Chapter 10 Europe Enzyme Replacement Therapy Analysis and Forecast
   10.1 Introduction
   10.2 Europe Enzyme Replacement Therapy Market Size Forecast by Country
      10.2.1 Germany
      10.2.2 France
      10.2.3 Italy
      10.2.4 U.K.
      10.2.5 Spain
      10.2.6 Russia
      10.2.7 Rest of Europe
   10.3 Basis Point Share (BPS) Analysis by Country
   10.4 Absolute $ Opportunity Assessment by Country
   10.5 Market Attractiveness Analysis by Country
   10.6 Europe Enzyme Replacement Therapy Market Size Forecast By Route of Administration
      10.6.1 Oral
      10.6.2 Parenteral
   10.7 Basis Point Share (BPS) Analysis By Route of Administration
   10.8 Absolute $ Opportunity Assessment By Route of Administration
   10.9 Market Attractiveness Analysis By Route of Administration
   10.10 Europe Enzyme Replacement Therapy Market Size Forecast By Therapeutic Condition
      10.10.1 Gaucher Disease
      10.10.2 Fabry Disease
      10.10.3 Pompe Disease
      10.10.4 SCID
      10.10.5 MPS Disease
      10.10.6 Other Diseases
   10.11 Basis Point Share (BPS) Analysis By Therapeutic Condition
   10.12 Absolute $ Opportunity Assessment By Therapeutic Condition
   10.13 Market Attractiveness Analysis By Therapeutic Condition
Chapter 11 Asia Pacific Enzyme Replacement Therapy Analysis and Forecast
   11.1 Introduction
   11.2 Asia Pacific Enzyme Replacement Therapy Market Size Forecast by Country
      11.2.1 China
      11.2.2 Japan
      11.2.3 South Korea
      11.2.4 India
      11.2.5 Australia
      11.2.6 South East Asia (SEA)
      11.2.7 Rest of Asia Pacific (APAC)
   11.3 Basis Point Share (BPS) Analysis by Country
   11.4 Absolute $ Opportunity Assessment by Country
   11.5 Market Attractiveness Analysis by Country
   11.6 Asia Pacific Enzyme Replacement Therapy Market Size Forecast By Route of Administration
      11.6.1 Oral
      11.6.2 Parenteral
   11.7 Basis Point Share (BPS) Analysis By Route of Administration
   11.8 Absolute $ Opportunity Assessment By Route of Administration
   11.9 Market Attractiveness Analysis By Route of Administration
   11.10 Asia Pacific Enzyme Replacement Therapy Market Size Forecast By Therapeutic Condition
      11.10.1 Gaucher Disease
      11.10.2 Fabry Disease
      11.10.3 Pompe Disease
      11.10.4 SCID
      11.10.5 MPS Disease
      11.10.6 Other Diseases
   11.11 Basis Point Share (BPS) Analysis By Therapeutic Condition
   11.12 Absolute $ Opportunity Assessment By Therapeutic Condition
   11.13 Market Attractiveness Analysis By Therapeutic Condition
Chapter 12 Latin America Enzyme Replacement Therapy Analysis and Forecast
   12.1 Introduction
   12.2 Latin America Enzyme Replacement Therapy Market Size Forecast by Country
      12.2.1 Brazil
      12.2.2 Mexico
      12.2.3 Rest of Latin America (LATAM)
   12.3 Basis Point Share (BPS) Analysis by Country
   12.4 Absolute $ Opportunity Assessment by Country
   12.5 Market Attractiveness Analysis by Country
   12.6 Latin America Enzyme Replacement Therapy Market Size Forecast By Route of Administration
      12.6.1 Oral
      12.6.2 Parenteral
   12.7 Basis Point Share (BPS) Analysis By Route of Administration
   12.8 Absolute $ Opportunity Assessment By Route of Administration
   12.9 Market Attractiveness Analysis By Route of Administration
   12.10 Latin America Enzyme Replacement Therapy Market Size Forecast By Therapeutic Condition
      12.10.1 Gaucher Disease
     12.10.2 Fabry Disease
      12.10.3 Pompe Disease
      12.10.4 SCID
      12.10.5 MPS Disease
      12.10.6 Other Diseases
   12.11 Basis Point Share (BPS) Analysis By Therapeutic Condition
   12.12 Absolute $ Opportunity Assessment By Therapeutic Condition
   12.13 Market Attractiveness Analysis By Therapeutic Condition
Chapter 13 Middle East & Africa (MEA) Enzyme Replacement Therapy Analysis and Forecast
   13.1 Introduction
   13.2 Middle East & Africa (MEA) Enzyme Replacement Therapy Market Size Forecast by Country
      13.2.1 Saudi Arabia
      13.2.2 South Africa
      13.2.3 UAE
      13.2.4 Rest of Middle East & Africa (MEA)
   13.3 Basis Point Share (BPS) Analysis by Country
   13.4 Absolute $ Opportunity Assessment by Country
   13.5 Market Attractiveness Analysis by Country
   13.6 Middle East & Africa (MEA) Enzyme Replacement Therapy Market Size Forecast By Route of Administration
      13.6.1 Oral
      13.6.2 Parenteral
   13.7 Basis Point Share (BPS) Analysis By Route of Administration
   13.8 Absolute $ Opportunity Assessment By Route of Administration
   13.9 Market Attractiveness Analysis By Route of Administration
   13.10 Middle East & Africa (MEA) Enzyme Replacement Therapy Market Size Forecast By Therapeutic Condition
      13.10.1 Gaucher Disease
      13.10.2 Fabry Disease
      13.10.3 Pompe Disease
      13.10.4 SCID
      13.10.5 MPS Disease
      13.10.6 Other Diseases
   13.11 Basis Point Share (BPS) Analysis By Therapeutic Condition
   13.12 Absolute $ Opportunity Assessment By Therapeutic Condition
   13.13 Market Attractiveness Analysis By Therapeutic Condition
Chapter 14 Competition Landscape
   14.1 Enzyme Replacement Therapy Market: Competitive Dashboard
   14.2 Global Enzyme Replacement Therapy Market: Market Share Analysis, 2019
   14.3 Company Profiles (Details – Overview, Financials, Developments, Strategy)
      14.3.1 AbbVie inc.
      14.3.2 Alexion Pharmaceuticals,Inc.
      14.3.3 Allergan
      14.3.4 BioMarin
      14.3.5 Horizon Therapeutics plc.
      14.3.6 Leadiant Biosciences, Ltd.
      14.3.7 Pfizer Inc.
      14.3.8 PROTALIX BIOTHERAPEUTICS, INC.
      14.3.9 RECORDATI S.p.A
      14.3.10 Sanofi
      14.3.11 Takeda Pharmaceutical Limited

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FAQ Section

Some frequently asked questions about this report!

1. Can I ask for different company profiles?

Additional company profiles can be provided on request.

2. Does this report also cover therapeutic condition specific details?

Yes, the report covers therapeutic condition specific information.

3. How big will be the Enzyme replacement market in 2027?

According to this Growth Market Reports report, the market from enzyme replacement is likely to register a CAGR of 6.8% during forecast period 2020-2027, with an anticipated valuation of USD 16,362.2 million by the end of the 2027.

4. What additional data analysis is available in report?

In addition to market size (in USD Million), company Market Share (in % for base year 2019), other data such as COVID-19 Impact on the enzyme replacement market, Macro-economic factors are available in the final report.

5. What are the factors driving the growth of enzyme replacement market?

The increasing plantation activities for fulfilling the accelerated demand for enzyme replacement is to drive the market growth.

6. What is the criteria used for selecting company profile?

Factors such as competitive strength and market positioning are key areas considered while selecting top companies to be profiled.

7. What is the impact of COVID-19 on the overall market during year 2019 -2020?

The market is expected to witness slight decline between 2019 and 2020 owing to the impact of COVID-19 pandemic on the enzyme replacement market.

8. Which is the base year calculated in the global enzyme replacement market report and what is analysis period?

The base year considered for the global enzyme replacement market report is 2019. The complete analysis period is 2017 to 2027, wherein, 2017 & 2018 are the historic years and the forecast is provided from 2020 to 2027.

9. Who are the key end-users driving the market growth?

Hospitals, clinics are the key end-user that are driving the enzyme replacement market.

10. Who are the major players operating in the market?

Major Manufactures include, Sanofi, Takeda Pharmaceutical Company Limited, BioMarin, AbbVie Inc, Alexion Pharmaceuticals, Inc., Horizon Therapeutics plc, RECORDATI S.p.A., PROTALIX BIOTHERAPEUTICS, INC., Allergan, Pfizer Inc., and Leadiant Biosciences, Ltd.